Magnesium And Depression

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Overview of Nexium

Nexium (esomeprazole magnesium), produced by AstraZeneca , is approved by the Federal Drug Administration (FDA) for the treatment of the following conditions: Dyspepsia, Peptic ulcer disease (PUD), Gastroesophageal reflux disease (GERD), Laryngopharyngeal reflux, Barrett's esophagus, the prevention of stress gastritis, Gastrinomas and other conditions that cause hypersecretion of acid and Zollinger-Ellison syndrome. It can be administered by injection through an IV or can be taken orally as a capsule in twenty or forty milligram dosages which are taken once or twice per day for a period of not more than fourteen days as recommended by the FDA. The medication is now produced by several pharmaceutical companies under the names, Prilosec, Aciphex, Dexilant, Zegrid, Prevacid, and Protonix. Nexium (esomeprazole) is AstraZeneca’s best-selling drug and the third best-selling medication in the world, with over $5.2 billion in sales in 2008.

The medicine belongs to a class of drug called Proton Pump Inhibitors (PHI). Their main function is a pronounced and long-lasting reduction of gastric acid production. This group of drugs followed and has largely replaced the use of H2-receptor antagonists with similar effects, but different mode-of-action. The main difference between the two classes are PPI’s stop proton pumps in the stomach from producing gastric acid, whereas the H2’s block the action of histamine on parietal cells in the stomach, decreasing the production of acid by these cells.

Generally, Nexium and other drugs of this type are well tolerated by patients and adverse effects from short-term use are not very common. Although adverse side effects are reported more often with the use of omeprazole, the same risks apply for all PPI’s. It is believed the occurrence is elevated in the use Nexium and similar medications because they are prescribed more than other PPI’s. Common side effects include: headache, nausea, diarrhea, abdominal pain, fatigue, and dizziness. Long-term use of PPI’s has been linked to hypomagnesemia. Because the body uses gastric acid to release B12 from food particles, decreased vitamin B12 absorption may occur with long-term use of proton-pump inhibitors and may lead to Vitamin B12 deficiency. Infrequent adverse effects include rash, itch, flatulence, constipation, anxiety, and depression. Rarely PPI cause ‘idiosyncratic’ reactions such as erythema multiforme pancreatitis, Stevens Johnson syndrome, and acute interstitial nephritis. Also, studies have shown using H2-receptor antagonists and proton pump inhibitors, are associated with an increased risk of community-acquired pneumonia. It is suspected that acid suppression results in insufficient elimination of pathogenic organisms, suggesting that patients at higher risk of pneumonia should be prescribed PPI’s only at lower doses and only when necessary. PPIs have been shown to raise risk of Clostridium difficile infection by 1.7 times with once daily use and 2.4 times with more than once daily use. The risk can be minimized by judicious short term prescriptions.

Suicide, Depression and Magnesium Deficiency | Psychology Problems ...

Suicide, Depression and Magnesium Deficiency

Article by Mervyn Penny

Most approaches to the problem of “Suicidal Thoughts” center around counseling, followed by drug treatment. I do not believe that either path would have much significant effect in the outcome. The counseling approach will no doubt work in some instances, but the actual reality in a large number of cases this approach simply will not work, people who consider suicide do so because they wish to escape from the way they feel or the pain they are feeling. Reassuring words are not suddenly going to make everything right, they need help, tangible help, not words that help the speaker far more than the person with the problem.

This comforting talk will only delay the inevitable, but it will not deter the person who is hell-bent on following the path to self destruction. There has to be a better way and I believe that there is a better way. It is not through counseling and certainly not through the poisons that will be prescribed by the medical profession. Drugs such as “Prozac” do have some potentially nasty side effects. Listen to this crap from the manufacturer of Prozac, then decide if you would agree to your depressed child being prescribed this poison: “Side effects of Prozac are minor and either does not require medical attention or can be treated easily. However, if you develop any serious problems, such as suicidal thoughts or behavior, hallucinations, or panic attacks, notify your healthcare provider immediately”. Another one: “Antidepressent medicines may increase suicidal thoughts or actions in some children, teenagers and young adults in the first few months of treatment”, the first few months? that’s when they need the most help!, not some antagonist drug that may well push them over the line.

Even before Prozac was first approved in the USA back in December 1987, there were more than 15 suicides linked to it. The Food and Drug Administration (FDA) knew this but failed to do anything about it.

What garbage is this?, you go to a so called “health care professional” to get help for your child with a mental disorder and this so called “professional” prescribes this crap. The medicine which is supposed to help is only going to aggravate the problem further, much better off doing nothing. I also bet this doctor fails to pre-warn you of these likely unwanted possible side-effects of his poison, that is of course if he knows anything about them, which I doubt. Your family doctor is notorous for not keeping up with the latest medical developements.

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